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This study reports an experience with 58 Wistar adult rats who sustained acute midthoracic spine cord injury due to Fogarty’s balloon-compression technique. This experience was approved by the institutional animal care and use committee (CEEA-IB-Unicamp). In the first step all the animals, sham and experimentals, were anesthetized with intraperitoneal pentobarbital 60 mg/Kg. The catheter was inserted into dorsal epidural space through a small hole made in the ligamentum flavum, advanced cranially to midthoracic spinal level, and inflated with 20 microlitres of saline only in the experimental group. The present study was performed to investigate the relationship between the spine cord injury and the time of compression (5, 15, 30 or 60 seconds). Quantitative neurological outcome was presented with 4, 24 and 48 hours from the compression to characterize the graduation of injury in different groups. The poor outcome occured with 60 seconds compression i n d ependentely of the time of neurological examination. Some animals died suddenly with pulmonary edema and a second step investigation was done to elucidate it. The aim of this second study was to show a model of neurogenic pulmonary edema due to thoracic spine injury using a Fogarty’s balloon containing 20 microlitres of saline during 60 seconds of compression (n = 17). There were used two different group of anesthesics to compare the influence of the drugs on the pulmonary edema and three groups were constituted: sham (1), compression /

Contribution to the study of the spinal cord changes during experimental model of the acute spinal cord injury