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A case suggestive of Creutzfeldt-Jakob disease in an adult with widespread lesions of the cerebral cortex, striatum and the spinal cord is reported. Anatomopathological studies showed neuronal degeneration, astrocytic proliferation, intense lymphoplasmocytic activity and slight spongiform degeneration. This inflammatory lymphocytic infiltration corroborates the hypothesis of viral etiology of this disease.

Degeneração cortico-estriato-medular: relato de um caso com achados clínicos e patológicos sugestivos de doença de Creutzfeldt-Jakob