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Retinitis pigmentosa (RP) is a disease which is characterized by progressive impairment of retinal photoreceptor cells. Ot has significant genetic heterogeneity (Sorrentino et al., 2016). The patients with early RP present the night blindness, followed by peripheral visual field defect, which eventually leads to the loss of central vision (Peli et al., 2016). RP is known as one of the most important diseases that cause the visual impairment in humans, and there is no effective treatment in clinic. At present, the gene therapy, photoreceptor cell transplantation and drug intervention are the main methods for the treatment of RP, and they still have limitations to varying degrees (Shintani et al., 2009). Seeking medicines by drug screening will be an effective way for the treatment of RP. Semen cassiae is the mature seed of Leguminosae cassia. On traditional Chinese medicine, Semen cassiae is sweet and slightly cold. Ot can enter the liver meridian, and acts as a good medicine in clearing liver and improving vision and relaxing bowels (Zhou et al., 2017). On addition, Semen cassiae can be used to for the treatment of cataracts, retinitis, optic nerve atrophy, glaucoma, conjunctivitis and other ophthalmic diseases (Dong et al., 2017). Polysaccharide is one of the main components of Semen cassiae (Cheng et al., 2018). Whether polysaccharide is related to the therapeutic effect of Semen cassiae on ophthalmic diseases, especially RP, has not been reported. Ot is found that, the changes of B-cell lymphoma-2 (Bcl-2), Bcl-2 associated X (Bax) and Cysteinyl aspartate-specific proteinase-3 (Caspase-3) protein expressions in retina tissue are involved in the occurrence and development of RP (Lin et al., 2017a; Garcia-Delgado et al., 2018). This study investigated the protective effects of water-soluble Semen cassiae polysaccharide (SCP) on RP in rats and explored the related mechanisms. The objective was to provide a basis for clinical application of SCP to prevention and treatment of RP.

Effects and mechanisms of water-soluble Semen cassiae polysaccharide on retinitis pigmentosa in rats