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Ulcerative colitis (UC) is a chronic, non-specific, inflammatory disease in which lesions are mainly located in the colonic mucosa (Meade et al., 2008). The precise etiology and pathogenesis of UC remain unclear. UC is associated with chronic disease and easy and repeated recurrence. Therefore, it is difficult to diagnose and treat in clinical practice. The World Health Organization (WHO) classifies UC as a modern refractory disease. In recent years, UC morbidity rates have been increasing (Dhamija et al., 2014) due to the influence of factors such as dietary habit changes and aggravated mental stress. Currently, no specific targeted treatment is available for UC in Western medicine (Meade et al., 2008); comparatively speaking, traditional Chinese medicine (TCM) and its preparations are more effective. TCM UC treatment can not only relieve the clinical symptoms of UC, but can also effectively prevent recurrence (Sandborn et al., 2016).

CircRNA malignant fibrous histiocytoma amplified Sequence 1 (MFHAS1) reduced inflammatory responses in a Colitis Model via SIRT1/NF-κB