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Sophora flavescens Ait. is a traditional Chinese herbal medicine. Ot has anti-tumor, anti-inflammatory, and antiviral effects (Zheng et al., 2013; He et al., 2015). Matrine is the main active ingredient of Sophora flavescens. Ot is an important alkaloid, which has a high inhibitory rate on some tumor cells and transplanted tumors (Zhang et al., 2009; Liu et al., 2010). Nasopharyngeal carcinoma (NPC) is a common malignant tumor in Southeast Asia and southern China. About 92% of NPC cases occur in the less developed areas (Feng et al., 2011). Radiotherapy is the main treatment modality for NPC. The radical radiotherapy can achieve good curative effect for most early-stage NPC patients which can obtain long-term survival after treatment (Lee et al., 2002). However, the pathogenesis of NPC is often occult, and the patients do not have any discomfort. When diagnosed in the clinic, the majority of NPC patients are in advanced stage. Although the radiotherapy equipment and technology are constantly updated and improved, the recurrence rate and distant metastasis rate radiotherapy is high. Chemotherapy still occupies an important position for patients with advanced NPC. The current first-line chemotherapy drugs include platinum compounds and 5-fluorouracil (Chan et al., 2002). However, some NPC patients, especially in advanced stage, have tolerance to these two drugs (You et al., 2015). Therefore, seeking effective and less-toxic drugs has important significance for the treatment of NPC, and it is one of the focuses in clinical research. At present, the research on the application of matrine to treatment of NPC is less reported. B-cell lymphoma-2 (Bcl-2) and Cysteine aspartic acid specific protease-3 (Caspase-3) are the proteins which play an important role in signal transduction of apoptosis (Zhan et al., 1999). This study investigated the extraction and purification technology of matrine from Sophora flavescens Ait. and the inhibitory effects of matrine on human NPC CNE-2 cells and the mechanism related to Bcl-2 and Caspase-3 protein expressions. The objective was to provide an experimental basis to further application of matrine to treatment of NPC.

Extraction of matrine from Sophora flavescens Ait. and evaluation of its inhibitory effects on human nasopharyngeal carcinoma CNE-2 cells