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Carlos Dornels Freire de Souza 0000-0003-0837-8254 Statistical analysis; Approval of the final version of the manuscript; Conception and planning of the study; Elaboration and writing of the manuscript; Obtaining, analyzing and interpreting the data; Effective participation in research orientation; Intellectual participation in propaedeutic and/or therapeutic conduct of the cases studied; Critical review of the literature; Critical review of the manuscript thorough analysis is necessary. On the other hand, the proportion of news casses with GPD II at diagnosis showed an increasing trend (AAPC 2%, p<0.01). This finding reinforces the existence of a late diagnosis and little effectiveness of the activities of timely case detection, supporting the hypothesis of a high hidden prevalence.2,5 Regarding the proportion of GPD among newly-diagnosed cases, there was an increasing trend between 2001-2015. When considering the whole period, the pattern observed was stationary (AAPC 0.3%, p=0.3). The variation in the proportion of GPD evaluated at the time of discharge is highlighted. In this indicator, three significant trends were observed: the first of decrease, between 2001 and 2007 (AP -1.5%, p<0.01), the second of increase, between 2007 and 2010 (APC 8.6, p<0.01) and the third of decrease, between 2010 and 2015 (APC-1.4, p<0.01). When considering the whole period, the pattern observed was stationary. These two indicators are capable of monitoring the quality of health services in patient care.4 Despite the improvement observed, we believe the services still have a long way to go to be able to offer an adequate care to patients, both for diagnosis and prevention of disabilities. It is important to highlight the differences between the percentages of evaluation at diagnosis, which was considered average for the period (between 75% and 90%) and at cure, considered poor (lower than 75%). Finally, we highlight the need to implement actions that allow for improvement in health services provide an early diagnosis, timely treatment and appropriate follow-up of patients, and, therefore, achieve a sustainable and real reduction of the burden of Hansen’s disease in Brazil. q

Patterns of proliferation and apoptosis in different subtypes of basal cell carcinoma, adjacent epidermis, and recurrent forms