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Three new taxa of subtribe Hyptidinae (Lamiaceae) from Amazonian Brazil are here described: two from Pará state Eriope macrostachya var. amazonica, and Hyptis cachimboensis, and Hyptis spathulata from Rondônia state. The diagnostic characters, which distinguish them from their closest relatives are described and discussed, their conservation status is given and a plate is provided for each of the new taxa. The Hyptidinae conspectus an earlier checklist of Lamiaceae from Amazonian Brazil is updated with various name changes since its publication, and with the addition of another two species of Hyptis not previously included. Also included, is a note on Hyptis sect. Eriosphaeria, to which the two new species described here, belong.

Updating the checklist of subtribe Hyptidinae (Lamiaceae) from Brazilian Amazonia, with three new taxa and notes on Hyptis sect. Eriosphaeria