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I t i s a n o u t s t a n d i n g p r i v i l e g e t o h a v e b e e n i n v i t e d t o t h i s S y m p o s i u m . T h e r e f o r e , I nould l i k e f i r s t t o t h a n k a l l t h o s e c o n c e r n e d w i t h t h e d e c i s i o n t o g r a n t me t h i s h o n o u r bn the o c c a s i o n o f t h e 8th S y m p o s i u m o n M e d i c i n a l P l a n t s o f B r a z i l . Mode rn t i m e s owe much t o t r a d i t i o n a l m e d i c i n a l u s e o f p l a n t d r u g s t h a n a c u r s o r y alance w o u l d r e v e a l . P l a n t p r o d u c t s h a v e b e e n w i t h man t h r o u g h a l l h i s t o r y s o that t h e i r effects b e t e s t e d a n d s c r u t i n i z e d t h r o u g h e n d l e s s t r i a l s o f a h i t o r m i s s n a t u r e . l t w a s çnly a f t e r t h e m e d i c i n a l c h e m i s t h a d p r i e d i n t o t h e n a t u r e o f t h e c h e m i c a l s e c r e t s o f lhe f o l k r e m e d i e s t h a t m a j o r d r u g s s u c h a s b e l l a d o n a , d i g i t a l i s , e r g o t , q u i n i n e , r e s e r p i r e etc., moved i n t o p r o m i n e n c e a s r e l i a b l e a n d i m m e n s e l y u s e d d r u g s . T h e u n t a p p e d v a s t f l o r a of N i g e r i a i n p a r t i c u l a r a n d o f W e s t A f r i c a i n g e n e r a l i s w e l l r e c o g n i z e d and the c o n s c ious efforts t h a t a r e b e i n g made by s c i e n t i s t s t o e x p l o i t t h e c o n s t i t u e n t s f r o m t h e p l a n t s growing i n t h i s s u b r e g i o n , w h i c h h a v e b e e n p r o v e d t r a d i t i o n a I l y t o be o f med i c i na 1 v a l u e llave s t a r t e d t o y i e l d p r o m i s i n g r e s u l t s . The l i t e r a t u r e i s a b u n d a n t w i t h e x a m p l e s o f new a n d p r e v i o u s l y known c o m p o u n d s Isolated f r o m m e d i c i n a l p l a n t s g r o w i n g i n t h e s u b r e g i o n w i t h 1 i t t 1 e t h o u g h t t o t h e poss_i_ He b i o l o g i c a l a c t i v i t y t i e d up w i t h t h o s e n o v e l m o l e c u l e s . A s p o i n t e d o u t by W i t k o p , Í970 , t h e i s o l a t i o n a n d s t r u c t u r a l e l u c i d a t i o n o f new c o m p o u n d s f r o m p l a n t m a t e r i a 1 s i s S t i l l j u s t a p r o l o g u e , t h e d r a m a d o e s n o t u n f o l d u n t i l t h e s e " c h i l d r e n " o f n a t u r e a r e taken by man a n d a r e r e t u r n e d t o p a r t i c i p a t e i n t h e d y n a m i c s o f l i f e i n o t h e r s y s t e m s . This p a p e r r e v i e w s t h e r e s u l t s o f r e s e a r c h c a r r i e d o u t o n some m e d i c i n a l p l a n t s g r o w i n g West A f r i c a w h i c h h a v e b e e n i n v e s t i g a t e d c h e m i c a l l y a n d w i t h p r o v e n b i o I og i c a I a c t iyi_ ty. T h i s r e v i e w h a s b e e n c i r c u m s c r i b e d by t h e c o n d i t i o n t h a t i t s h o u l d d e a l w i t h n a t u ral p r o d u c t s o f p r o v e n c h e m i c a l s t r u c t u r e s a n d s h o w i n g some k i n d o f b i o l o g i c a l a c t i v i t y or o t h e r . T h e a p p r o a c h a d o p t e d h a s b e e n r a t h e r s e l e c t i v e a n d t h e p r e s e n t a t i o n i s b a s e d on a c l a s s i f i c a t i o n a c c o r d i n g t o c h e m i c a l s t r u c t u r e .

Chemical and biological investigations on medicinal plants of west Africa