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ATP-Binding Cassette (ABC) transporters are involved in cholesterol metabolism and their dysfunctions could lead to obesity-associated complications. It was investigated whether SNPs in the  ABCA1  (rs1800977 and rs2230806),  ABCA7  (rs2279796) and  ABCG1  (rs692383 and rs3827225) genes can modulate the responsiveness of 137 obese women to a weight-loss dietary intervention. Thus, anthropometric and lipid profiles were collected at baseline and after nine weeks of a calorie-restricted diet of 600kcal per day and participants were genotyped for the  ABC  genes SNPs. Regarding the transversal analysis, the  ABCA7  rs2279796 GG genotype was associated with higher levels of total cholesterol and LDL-c at baseline (p = 0.044 for both). Association between  ABCG1  rs692383 AA genotype and lower BMI were found in the post-diet moment, however, statistical significance was lost after multi-test correction. Regarding the longitudinal analysis, after multi-test correction, the association remained between  ABCG1  rs692383 G allele and HDL-c levels: G allele carriers had a lower HDL-c reduction (p = 0.043). Results suggest the standard weight-loss diet applied in this study could attenuate the  ABCA7  rs2279796 GG genotype effects found at baseline and non-dyslipidemic obese women with  ABCG1  rs692383 G allele are benefitting from the diet with a lower reduction in HDL-c levels.

Is it possible ABC transporters genetic variants influence the outcomes of a weight-loss diet in obese women?