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OmniGen-AF is a commercially available, patented, proprietary, branded feed additive that exerts immunomodulatory effects in nonruminant (Branson et al., 2016) and ruminant species (Wang et al., 2009; Nace et al., 2014; Brandão et al., 2016). Therefore, there are many gaps in the understanding of how this feed additive acts on the immune system. In addition, the majority of studies of this additive have focused on investigating its effect on the innate immune response, and its effect on the adaptive immune response is largely unknown. Nonetheless, we hypothesized that its implications are far-reaching and that it may also impact adaptive immunity functions, such as lymphocyte proliferation.

Lymphocyte proliferative responses in dairy cows supplemented with an immunomodulatory feed additive and administered polyvalent vaccination