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Objective:  to compare the direct cost, from the perspective of the Unified Health System, of assessing the post-vaccination serological  status  with post-exposure management for hepatitis B among health care workers exposed to biological material.    Method:  cross-sectional study and cost-related, based on accident data recorded in the System of Information on Disease Notification between 2006 and 2016, where three post-exposure and one pre-exposure management scenarios were evaluated: A) accidents among vaccinated workers with positive and negative serological  status  tests for hepatitis B, exposed to known and unknown source-person; B) handling unvaccinated workers exposed to a known and unknown source-person; C) managing vaccinated workers and unknown serological  status  for hepatitis B and D) cost of the pre-exposure post-vaccination test. Accidents were assessed and the direct cost was calculated using the decision tree model.    Results:  scenarios where workers did not have protective titles after vaccination or were unaware of the serological  status  and were exposed to a positive or unknown source-person for hepatitis B.    Conclusion:  the direct cost of hepatitis B prophylaxis, including confirmation of serological  status  after vaccination would be more economical for the health system.

Post-vaccination anti-HBs testing among healthcare workers: More economical than post-exposure management for Hepatitis B