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The study of animal models is of key relevance in biomedical research. Animal models of psychiatric disorders have been important tools to gain insight into the presumed mechanisms of psychoses and mood and anxiety disorders in the last several decades. These models have largely focused on the improvement of specific aspects of validity. 1 Our current psychopharmacological treatments came from these preclinical models for diverse psychiatric disorders. They provided not only a screening for identifying and further developing these compounds but also helped to clarify neurobiological aspects underlying psychiatric disorders. However, despite these gains, animal models have also contributed to the relatively little progress in developing new and improved therapeutics for human psychiatric disorders – existing medications are largely refinements of older versions and have not been demonstrated to be superior

brazilian journal of psychiatry

Next-generation strategies in animal model research to translate preclinical discoveries into better treatments for circuit-centered psychiatric dimensions