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portuguesAvancos nos campos glicobiologia e imunologia forneceram muitas informacoes sobre o papel das interacoes da proteina-carboidrato na modulacao do sistema imunologico. A jacalina extraida de Artocarpus integrifolia (JCA) e a manoproteina da parede celular de Saccharomyces uvarum (MPS) sao moleculas com propriedades imunomoduladoras. JCA e uma lectina com afinidade pela IgA humana e tem acao mitogenica sobre celulas do sistema imunologico estimulando a producao de citocinas, a quimiotaxia e a ativacao de leucocitos. Estudos sobre as propriedades imunomoduladoras de JCA e MPS em mamiferos e peixes sugerem que essas moleculas podem ter um efeito sobre a producao de anticorpos. O objetivo deste estudo foi investigar a acao da JCA e MPS sobre a producao de anticorpos especificos em galinhas poedeiras. Para isso, galinhas poedeiras foram inoculadas por via intra-abdominal com eritrocitos de carneiro (SRBC) em associacao com o JCA (0,075 µg, 0,75 µg, e 7,5 µg) ou MPS (20 µg e 100 µg). Os niveis de anticorpos anti-SRBC das classes IgY, IgM, e IgA foram avaliados por ELISA. Os resultados mostraram que a JCA e a MPS tem um efeito imunomodulador sobre a producao IgY, IgM, ou IgA anti-SRBC. Um efeito imunoestimulador da JCA foi observado sobre a producao de anticorpos IgY na resposta imune primaria, enquanto um efeito imuno inibitorio da JCA e da MPS sobre a producao de IgM e IgA anti-SRBC na resposta imune secundaria. Estes resultados sugerem que o MPS e JCA tem efeito modulador sobre a producao de anticorpos e podem ser utilizados em estudos futuros sobre a imunidade humoral em aves comerciais EnglishAdvances in the fields of glycobiology and immunology have provided many insights into the role of carbohydrate-protein interactions in the immune system. Jacalin of Artocarpus integrifolia (JCA) and structural mannoprotein of Saccharomyces uvarum (MPS) are molecules with immunomodulatory properties. JCA is an IgA human lectin binding molecule that causes the mitogenic stimulation of immune cells, production of cytokines, chemotaxis, and activation of leukocytes. Studies on the immunomodulatory properties of JCA and MPS in mammals and fish suggest that they have an action on antibody production. The aim of this study was to investigate the possible action of JCA and MPS on the production of specific antibodies in laying hens. For this, laying hens were inoculated with an intra abdominal injection of sheep red blood cells (SRBC) with either JCA (0.075 µg, 0.75 µg, and 7.5 µg) or MPS (20 µg and 100 µg). Levels of anti-SRBC antibodies of the IgY, IgM, and IgA classes were evaluated by ELISA. Results showed that JCA and MPS have immunomodulatory effects on levels of anti-SRBC IgM, IgA, and IgY. An immunostimulatory effect of JCA was observed in primary immune response on anti-SRBC IgY, while an inhibitory effect of JCA and MPS was observed in secondary immune response on the production of IgM and IgA anti-SRBC. These results suggested that MPS and JCA have immunomodulatory effects on antibody production and could be used in future studies on humoral immune response in poultry

Immunomodulatory action of jacalin from Artocarpus integrifolia and mannoprotein from Saccharomyces uvarum on the humoral immunity of laying hens