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portuguesMeningiomas sao neoplasias que comumente envolvem o sistema nervoso central de gatos, enquanto colesteatomas sao formacoes nodulares granulomatosas raramente descritas nessa especie e que resultam de lesoes cronicas em plexo coroide. O objetivo desse trabalho e descrever um caso de meningioma em terceiro ventriculo culminando com a formacao de colesteatoma e hidrocefalia nao comunicante em um gato. Clinicamente, o gato apresentava alteracao de comportamento, fotofobia e incoordenacao motora durante dois anos. A necropsia apresentava uma massa acastanhada no terceiro ventriculo que provocava oclusao total do mesmo e acentuada dilatacao de ventriculos laterais (hidrocefalia nao comunicante). Microscopicamente, havia proliferacao neoplasica de celulas fusiformes arranjadas em feixes com a formacao de corpos psamomatosos (meningioma), e em area adjacente havia multiplas fendas de colesterol e hemossiderose com infiltrado granulomatoso (colesteatoma). A imuno-histoquimica (IHQ), foi observada marcacao positiva para vimentina e negativa para citoqueratina e S100 nas celulas neoplasicas. Os exames histologicos e de IHQ contribuiram para a confirmacao do diagnostico de meningioma transicional associado a formacao de colesteatoma e hidrocefalia nao comunicante, e sao metodos importantes para diferenciar de outras afeccoes que cursam com quadro clinico neurologico em felinos. EnglishMeningiomas are neoplasms that commonly involve the central nervous system of cats, while cholesteatomas are nodular granulomatous chronic lesions within the choroid plexus that are rarely reported in cats. This study described a case of cholesteatoma and non-communicating hydrocephalus associated to a third ventricle meningioma in a cat. Clinically, the cat had a 2-year history of behavioral changes, photophobia and motor incoordination. At the necropsy, a tan-brown mass totally occluded the third ventricle, causing a severe dilation of the lateral ventricles (non-communicating hydrocephalus). Microscopically, the mass was composed by a neoplastic proliferation of spindle cells arranged in bundles, containing in the center psammomatous bodies (meningioma), while in the adjacent areas a cholesteatoma was observed, which was characterized by multiple cholesterol cleft formation, hemosiderosis and associated granulomatous inflammation. At immunohistochemistry (IHC), neoplastic cells had a marked immunostaining for vimentin, while were negative for cytokeratin and S100. The diagnosis of transitional meningioma occurring in association to cholesteatoma and non-communicating hydrocephalus in a cat was obtained mainly by the histological and IHC features. These are important methods to distinguish this condition from other neurological disorders in cats.

Cholesteatoma and hydrocephalus associated to a third ventricle meningioma in a cat