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Objective: The objective of this article was to investigate the biopsychosocial factors that influence adherence to treatment and the quality of life of individuals who have been successfully following the HIV/AIDS treatment.   Methods: It is a cross-sectional study carried out with 120 HIV positive participants in the south of Brazil. Among the variables studied, of note are: perceived stress, social support, symptoms of anxiety and depression and quality of life.   Results: The results show that a moderate to high adherence to the treatment paired with a strong sense of social support indicate a higher quality of life.   Conclusion: The combination of social support and antiretroviral treatment have an impact on physical conditions, improving immune response and quality of life

Psychosocial factors associated with adherence to treatment and quality of life in people living with HIV/AIDS in Brazil