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A 49-year-old man who was diagnosed with diffuse large B cell lymphoma was treated with cyclophosphamide, doxorubicin, vincristine, and prednisone, plus the monoclonal antibody rituximab (R-CHOP protocol) and achieved a confirmed complete response. However, six months later, he complained of superior (upper) and inferior (lower) limb paresthesias. An MRI of the brachial plexus (Figure 1) and sacral plexus (Figure 2) showed diffuse root enlargement that also demonstrated hypermetabolism on PET-CT (Figure 1D and Figure 2D and 2E), characterizing a disease relapse. Despite the low frequency of occurrence, the clinician should also be aware of neuropathy as a symptom for disease

Brachial and sacral plexus neurolymphomatosis - unusual regions for disease relapses