English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A 50-year-old Portuguese man presented with a 4-yearhistory of slurred speech, behavioral changes and tetraparesis with sphincter disturbances. Medical history was positive for chronic lumbar pain with spondylosis and two strokelike episodes. Family history disclosed consanguineous parents. Examination showed alopecia, spastic tetraparesis, dysarthria and emotional instability. Neuroimaging revealed diffuse leukoencephalopathy (Figure), compatible with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL). CARASIL is a hereditary small vessel disease caused by mutations in HTRA1 gene (10q26.13) and characterized by recurrent strokes, progressive dementia and key systemic features such as lumbago, alopecia, arthropathy, spondylosis and disc herniation1,2.

Lumbago and alopecia in a patient with leukodystrophy: think on CARASIL