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.First, these exciting results were obtained at high-volume comprehensive stroke centers with large ex -perience with stroke therapy with TPA (including telemed-icine) and full-time stroke teams (with a stroke neurolo-gist), angiography suite and multimodal neuroimaging. The reproducibility of their results in our healthcare sys-tem requires organizing efficient stroke networks, able to identify candidates for EVT and promptly refer them to comprehensive stroke care center. This poses a special challenge in Brazil, given its continental dimensions, geo-economical disparities, and paucity of such comprehen-sive stroke units. We also need to train a new generation of stroke neurologists and interventionalists.Secondly, the underlying selection paradigm differed widely among trials, from being extremely restrictive in se-lecting patients (

A new era of endovascular treatment for acute ischemic stroke: what are the implications for stroke care in Brazil?