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Juvenile myoclonic epilepsy (JME) accounts for 26% of generalized idiopathic epileptic syndromes. The highest levels of thrombin activity are closely involved in the development of neurological diseases, including epilepsy. The prothrombin c.20210G&gt;A (rs1799963) variation, which alters prothrombin mRNA stability, is associated with high plasma prothrombin levels.

Lack of association between the prothrombin rs1799963 polymorphism and juvenile myoclonic epilepsy