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〔目的〕ラットヒラメ筋の廃用性萎縮進行中に間歇的伸張運動を実施し筋線維タイプ別の筋萎縮抑制効果を長軸部位の視点から検討することを目的とした〔対象〕Wistar系雄ラットヒラメ筋を対象とした〔方法〕ラットに対し通常飼育するCON群廃用性筋萎縮を惹起するHS群実験期間中間歇的伸張運動を行うST群の3群を設定実験期間終了後対象筋の近位部・中央部・遠位部で切片を作成しHE染色を行いATPase染色を実施し最後に筋線維横断面積を測定した〔結果〕筋線維横断面積はタイプI・II線維とも全ての部位でHS群と比較し有意に高くST群の中央部遠位部近位部の順に高値であった〔結語〕タイプI・II線維ともに筋萎縮抑制効果がみられ筋の長軸部位別にその効果が異なることが示唆される [Purpose] The purpose is the effects of intermittent stretching exercise on disuse atrophy of the rat soleus muscle with respect to sites and muscle type. [Subjects] Twenty-one 8-week-old male Wistar rats were used. [Methods] The rats were divided into 3 groups: the CON group which received standard breeding, the HS group in which disuse atrophy of the soleus muscle was induced by hind-limb suspension, and the ST group which received intermittent stretching exercise during the hind-limb suspension period. At the end of the suspension period, the soleus muscle was excised and cut into proximal, middle, and distal samples which were stained with hematoxylin-eosin and ATPase. Subsequently, the cross-sectional area (CSA) was measured. [Results] CSAs of both type I and II fibers were significantly higher in the ST group than in the HS group, and the values of the middle region were significantly higher than those of the distal region. Also, the values of the distal region were significantly higher than those of the proximal region. [Conclusion] The results suggest that atrophy of both type I and II fibers of disused muscles is inhibited by stretching, and that there are differences in effect among the longitudinal sites of the rat soleus muscle

Effect of Intermittent Stretching Exercise on the Fiber Types and Muscle Segments of the Rat Soleus Muscle in Disuse Atrophy