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Objective: This study was conducted to determine benefits of dexmeditomidine use as a post operative sedative agent in patients after cardiac surgery. Study Design and Duration: This is a comparative study of prospective randomized trial. Study was started in January 2018 and completed in September 2018 comprising on total duration of 9 months. Setting: This study was conducted in National institute of cardiovascular surgery Karachi. Patients and Methods: Patients admitted in the study institution and planned for any type of cardiac surgery were divided into three groups. After operation they were given three types of drugs for sedation dexmeditomidine, Midazolam and propofol and outcome of these drugs was recorded. Total 130 cases were included in this study. In two groups each comprising on 45 cases dexmeditomidine and Midazolam were given. In third group, consisted of 40 cases, propofol was given post operatively. Effects of these drugs were documented. Age of patients, hospital stay, mean ICU stay, incidence of delirium and male and female distribution of cases was documented. Patients having delirium after cardiac surgery were given haloperidol and lorazepam as a treatment. Results: Out of total 130 cases 45(34.6%) were given dexmeditomidine, other 45(34.6%) cases were given midazolam and 40(30.7%) cases were given propofol as asedative agent after cardiac surgery. Age range was 1865 years with mean age 43.5 years. In dexmeditomidine group there were 22% cases below 20 years, 33% between 20-40 years, 20% between 41-60 years and 13.3 cases above 60 years. In Midazolam and propofol groups 17.7% & 30% were below 20 years, 35.5% & 25% between 20-40 years, 37.8% & 32.5% between 41-60 years, 8.9% & 12.5% respectively were above 60 years. Incidence of delirium among the cases given dexmeditomidine was 6.7%, in midazolam group 40% and in propofol group was 37.5%. Conclusion: Dexmeditomidine is an effective drug in post operative patients after cardiac surgery as it reduces postoperative delirium in these patients and helps in early recovery of patients.

ROLE OF DEXMEDETOMIDINE IN CARDIAC SURGERY PATIENTS AND INCIDENCE OF DELIRIUM