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The article presents the results of a study conducted to study the informative value and prognostic significance of some cytokines and antimicrobial peptides in the early detection of metastases in patients with cervical cancer. For this purpose, in blood in 46 patients without lymph node metastases was determined the content of some cytokines (IL-2, IL-6, IL-10 and TNF-α) and antimicrobial peptides (endothelium, L-FABP, endotoxin, lactoferrin) by an enzyme immunoassay analysis. To determine the informativeness and prognostic significance of the studied indicators, was used a statistical dispersion of test ANOVA and ROC analysis. The results of the study showed a significant increase in proinflammatory cytokines and antimicrobial peptides in the serum of patients with cervical cancer. Elevated values were observed in those patients in whom various metastases to the lymph nodes were observed during the course of 6 months to 3 years. It has been established that IL-2, TNFα, IL-6, endothelin and L-FABP have prognostic and diagnostic significance for the early detection of metastases in patients with cervical cancer.

teoretičeskaâ i prikladnaâ nauka

STUDY OF INFORMATIVE VALUE AND PROGNOSTIC SIGNIFICANCE OF SOME CYTOKINES AND ANTIMICROBIAL PEPTIDES FOR EARLY DETECTION OF METASTASES IN PATIENTS WITH CERVICAL CANCER.