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RESULTS: The autophagic flux assay demonstrated that swimming training increased the autophagic flux (-3 fold increase in LC3-II, p<.05) in young mice, yet exhibited -2 fold increase in the autophagic flux in muscle of aged mice. The basal autophagy was also decreased in aged mice (LC3, p62, p<.05). Despite no changes in Beclin-1 proteins, other autophagy marker proteins (Bnip3, Lamp1, and HDAC6) were significantly decreased in aged mice compared with young mice ( p<.05). CONCLUSIONS: It is concluded that both basal and induced autophagy activated by exercise training was decreased in aged mouse skeletal muscle. The inhibited autophagy in skeletal muscle of aged mice was not reversed by endurance exercise training which activates autophagy in skeletal muscle.

Autophagy Flux Is Decreased in Response to Endurance Exercise Training in Aged Mouse Skeletal Muscle