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Three novel analogs of pochonicine ( 1 ) were isolated from a solid fermentation culture of the fungal strain Pochonia suchlasporia var. suchlasporia TAMA 87, and their structures were elucidated as 7-deoxypochonicine ( 2 ), 6-deoxypochonicine ( 3 ), and 6,7-dideoxypochonicine ( 4 ). These analogs were found to possess the same stereochemistry as pochonicine. Comparison of β- N -acetylglucosaminidase (GlcNAcase) inhibitory activity between these analogs and pochonicine suggested that the C-6 hydroxy group of pochonicine was essential to its potent GlcNAcase inhibitory activity and that the C-7 hydroxy group also contributed to the activity, but to a lesser extent than the C-6 hydroxy group.

nippon nōyaku gakkaishi

New analogs of pochonicine, a potent β-&lt;i&gt;N&lt;/i&gt;-acetylglucosaminidase inhibitor from fungus &lt;i&gt;Pochonia suchlasporia&lt;/i&gt; var. &lt;i&gt;suchlasporia&lt;/i&gt; TAMA 87