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To investigate the improving effect of 2-methacryloyloxyethy1 phosphoryl-choline (MPC) on skin barrier damage, skin irritation animal model was produced by the application of sodium dodecyl sulfate (SDS) to the backs of hairless mice for 1 week. And experimental materials were applied topically for 1 week during the same period. At the 7th day of experiment, positive control (PC, sodium hyaluronate 1%) and experimental groups [E1, C/L Poly (AA-Co-MPC 3w%) 0.5%; E2, C/L Poly (AA-Co-MPC 5w%) 0.5%, E3, C/L Poly (AA-Co-MPC 10w%) 0.5%] had significantly (p⁄0.05) lower values of both skin erythema index and water capacity than the vehicle control [VC, C/L Poly (AA) 0.5%] group. E2 and E3 groups had significantly (p⁄0.05) lower values of transepidermal water loss than the VC group. The appearance of mast cells in dermal and subcutaneous layers was remarkably reduced in E1, E2 and E3 groups compared to the VC group. It is found that MPC is effective in skin barrier damage in hairless mouse.

The Improving Effect of 2-methacryloyloxyethy1 phosphorylcholine (MPC) on Skin Barrier Damage in Hairless Mice