English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

To evaluate the alleviating effect of black tea water extract (BTWE) on skin wrinkle, the aging animal model was produced by 12 weeks-irradiation of UVB to the backs of 6~7 weeks old female SKH-1 hairless mice three times a week as each time intensity of 60 mJ/cm2 (1MED) at week 1; 2MED at week 2; 3MED at week 3; and 4MED at week 4~12. And then, BTWE was applied to the backs of the aging animals twice a day, 5 days a week for 4 weeks, 200 μL each time (BTWE 1%: 0.13 g/kg BW/day, 2%: 0.26 g/kg BW/day). Total wrinkle area for the control (C: UVB irradiation+saline treatment) group was 107.2% significantly (p⁄0.05) wider than the normal (N: no UVB irradiation) group. And those of the positive control (PC: UVB irradiation+0.01% retinoic acid application) and experimental (E1: UVB irradiation+1% BTWE application, E2: UVB irradiation+2% BTWE application) groups were significantly (p⁄0.05) narrower than the C group, as 48.2%, 41.5% and 46.4%, respectively. Collagen fibers were arranged irregularly and sparse in density and some elastic fibers were degenerated in the C group, while they were remarkably improved in the PC, E1 and E2 groups. MMP-3 mRNA expression in the C group was 645.4% significantly (p⁄0.05) higher than the N group, and those of PC, E1 and E2 groups were significantly (p⁄0.05) lower than the C group, as 76.8%, 65.9% and 78.0%, respectively. BTWE could have a considerable alleviating effect on skin wrinkle in hairless mice irradiated with UVB.

Alleviating Effect of Black Tea Water Extract on Skin Wrinkle in Hairless Mice Irradiated with UVB