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What makes the use of angioscopy so attractive? The most distinctive feature of coronary angioscopy is its ability to directly visualize the coronary artery; seeing is believing. Many coronary artery happenings are only able to be observed using angioscopy. Angioscopy is the only tool that allows the direct observation of plaque natural history, including its progression, sometimes its regression, and finally its rupture and the subsequent thrombus formation, in living patients. To date, coronary Coronary Artery Discoveries Made Using Direct Angioscopic Visualization: Fifteen Years of Experience and Further Expectations