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The normalized expression levels are combined to one numeric value which determines the drug susceptibility of the investigated strain. We successfully developed 8 primary sets of RNA biomarkers for ten 1-line, 2-line and new drugs. Taking isoniazid as proof of principle, we present a biomarker set of 5 responsive genes and 3 normalizing genes, which enables to distinguish susceptible, lowand high resistant TB strains after 6 hours incubation. Next, preliminary results demonstrate that the biomarker sets can successfully discriminate between susceptible and resistance strains for the selected drugs. We present a robust, RNA-based DST without the need for RNA extraction. The assay was proven to be efficient for isoniazid. With a total of 8 biomarker sets under optimization, the drug resistance profile of up to 14 drugs can be determined.

POPULATION STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS IN RUSSIAN REGIONS BORDERING EU COUNTRIES