English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The objective of the study is to examine the impact of the deletion of the MMP-1 gene on the development, expression, dynamics of clinical syndromes and the effectiveness of treatment in patients with pulmonary tuberculosis. 73 patients with pulmonary tuberculosis, receiving treatment in the hospital of the state health care facility “Regional TB Dispensary” in the city of Astrakhan. Depending on the genotype of MMP-1, three groups were formed: the first group — with G1/G1 — 15 people (20.5%), the second — with G2/G1 — 27 people (50.7%) and the third one — with G2/G2 — 21 people (28.8%). During the treatment, the disappearance of symptoms of intoxication and bronchopulmonary disorders in patients of the 1 and 2 groups occurred earlier than in the 3 group (χ = 11.5, p = 0.02). Dissolving of infiltration in the lung tissue also started earlier in the first and second groups (χ = 9.2, p < 0.05). The discharge of Mycobacterium tuberculosis (MBT) stopped earlier in patients of the 1 group. After four months of treatment, MBT were not determined by any method in 94.6% of the patients in the 2 group and in 90.4% in the 3 group (χ = 9.9 p = 0.07). Closure of decay cavities after 2 months of treatment was observed in 70% of cases in patients of the 1 group, in 53.6% of cases — of the second and in 15.6% of cases — of the third. In 47.4% of patients with G2/G2, destructive changes persisted for more than 4 months of treatment (χ = 10.3, p = 0.03). Patients with genotype G2/G2 have a tendency to a protracted tuberculosis. The study of the polymorphism of the MMP-1 gene in patients with pulmonary tuberculosis can be used as a prognostic criterion of the clinical course of tuberculosis, correction of specific therapy, and justification for prescribing drugs affecting collagen metabolism.

THE IMPACT OF THE DELETION OF THE MMP-1 GENE ON THE EXPRESSION OF SYMPTOMS AND THE EFFECTIVENESS OF TREATMENT IN PATIENTS WITH PULMONARY TUBERCULOSIS