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with drug-resistance, high transmissibility and clustering. But they do vary among endemic and sporadic strains, in different settings and hosts, even at within country level. Secondly, Russian epidemic clone Beijing B0/W148 was commonly regarded as widespread across all Former Soviet Union. In reality, its geographic distribution shows a peculiar clinal gradient with highest frequency in Siberia and sharp decrease in the Asian part of the former Soviet Union. Thirdly, a global spread of LAM RD-Rio sublineage has been claimed and was attributed to its particular pathogenic properties. A comprehensive analysis of available data shows that RD-Rio strains are rarely present in Russia and East Asia. It appears that there is no global dissemination of RD-Rio due to specific virulence properties of these strains but rather their spread due to human migration (if such migration did take place). A confusing terminology, misclassification and false clustering are not abstract issues but make a scientific discussion meaningless, and I will propose some courses for improvement of the situation. Funding: Russian Science Foundation grant 14-14-00292.

ANALYSIS OF SECONDARY RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS TO SECOND-LINE ANTI-TUBERCULOSIS DRUGS IN CASABLANCA