English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

from the same time period with the same genotype were included in the phylogenomic analysis. The genomic variants identified by WGS were used for phylogenomic inference, drug resistance prediction and to determine genomic distances between isolates. WGS analysis revealed unexpected genomic diversity within the seemingly homogenous IS6110 cluster of M. tuberculosis isolates. Despite the IS6110 RFLP based uniformity, at least six non-time dependent sub-clusters and several orphan-isolates were evident from the WGS-based phylogeny and genomic comparisons. Sub-clusters gained drug resistance conferring mutations (beyond MDR) on multiple occasions and M. tuberculosis isolates from surrounding suburbs were observed throughout the phylogeny. IS6110 RFLP typing underestimated the complexity of this 23-year outbreak. This study suggests that there is continuous circulation and reintroduction of this M. tuberculosis cluster in the community setting. Even with the advent of the WGS-era, confirming direct epidemiological links or outbreak directionality remains a challenge in high TB burden, low-income settings.

A 15-YEAR SPATIOTEMPORAL ANALYSIS OF MYCOBACTERIUM TUBERCULOSIS LINEAGES 1 AND 2 IN CHIANG RAI, THAILAND