English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The use of oncolytic viruses for biotherapy of tumors is a promising approach. It is assumed that the administration of some kinds of viruses into the tumor-bearing organism induces both direct and indirect antitumor effect. The potential use of Newcastle disease virus (NDV) in this field attracts attention of the researchers. Our aim was to study the effect of the administration of NDV vaccine strain on some indices of cell-mediated immunity in rats after transplantation of carcinoma. The experiment was performed on 19 white mongrel male rats with Guerin’s carcinoma. The NDV vaccine strain LaSota was inoculated once 5000 doses paratumorally 2 times a week, 4 times in total: in the first group of rats the course of NDV was started after tumor transplantation, in the second group — one week before tumor transplantation. Tumor growth was observed and lymphocytes̀ subsets were counted in peripheral blood samples collected from the femoral vein of animals in the dynamics of the course of NDV administration. The per cent of Tand B-lymphocytes were estimated by flow cytometer BD CantoII. The results showed stimulating effect of the NDV on the T-cell link of rats̀ immune system and made it possible to establish differences in the type of the immunological changes developing in tumor-bearing rats, depending on the time of administration of the virus relative to the time of tumor transplantation and their possible significance for obtaining a prophylactic effect on transplanted tumors in some animals. So the administration of NDV previous to tumor transplantation caused a marked increase of CD3CD25 (T cells expressing an early activation marker) and CD3CD4 lymphocytes̀ levels which persisted after tumor transplantation while the levels of CD3CD8 and CD3RT1b (T cells expressing a late activation marker) cells were decreased. This was the only group where in some rats tumor formation after transplantation was not observed or early regression was detected. On the contrary, in the control animals the highest CD3CD8 and the lowest CD3CD25 cells̀ levels were observed during the whole period. Administration of NDV to the rats of the first group after tumor transplantation produced effect neither on tumor growth nor on potentially antitumor factors of cell-mediated immunity. Thus we consider that if NDV is able to induce any antitumor effect it should be used before tumor transplantation; activation of Th cells should be achieved.

INFLUENCE OF THE NEWCASTLE DISEASE VIRUS ON SOME INDICES OF CELL-MEDIATED IMMUNITY IN TUMOR-BEARING RATS