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The specificity of examined sandwich-ELISA variants was high, the sensitivity widely varied. The best result (7 ng/ml of purified AV 6 type) was obtained with capture MAbs #1 and PX conjugate of these MAbs. For AV antigens detection in infected cell the most promising is MAbs #2 FITC conjugate that allows to detect AV of epidemic types in infected cells in form of nuclear localized clear fluorescence. Usage of MAbs for development of high sensitivity and specificity test-kits for differential diagnosis of AV infection provides new possibilities for medical practice. Diagnostic properties of developed sandwich-ELISA and MAbs #2 FITC conjugate will be investigated with clinical samples.

THE ROLE OF MOLECULAR-GENETIC RESEARCH IN THE SYSTEM OF EPIDEMIOLOGICAL SURVEILLANCE OVER ENTEROVIRUS INFECTION IN THE RUSSIAN FAR EAST AND SIBERIA