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The influenza sentinel surveillance system (ISS) in Russia includes 19 hospitals and 14 polyclinics located in Kaliningrad, St. Petersburg, Lipetsk, Moscow, Samara, Stavropol, Novosibirsk, Chita, Khabarovsk, Vladivostok. The standard definitions for SARI, ILI and ARI (according to WHO case definition) and case-based reporting were used in the study. The on-line data submission into the electronic database of the Smorodintsev Research Institute of Influenza from each Sentinel Site (SS) at the FBUZ Centers for Epidemiology and Hygiene was conducted on a weekly basis. Case-based form for each patient included the data on age, sex, date of disease onset, sampling for PCR, co-morbidity, ICU placement, the status of vaccination, treatment by antivirals, results the PCR detection of influenza viruses and other 7 respiratory viruses, outcome of the disease. Laboratory confirmed influenza (LCI) was registered in average in 20.8% of patients with SARI and in 16.3% of ILI/ARI patients. Severity of the clinical course of SARI determined as the proportion of SARI patients placed in the Intensive Care Unit of total SARI cases was estimated as 7.6%, LCI SARI cases as 2.3%. Influenza A(H3N2) virus caused 51.0% of SARI cases, influenza B (Yamagata lineage) and A(H1N1) pdm09 viruses were determined in 33.3 and 15.8%, respectively. The general trend of greater significance of LCI among SARI compared to the ILI/ARI was confirmed this season. Among 400 SARI patients with LCI only 17 (4.25%) patients were vaccinated. Among 320 LCI outpatients with ILI/ARI 22 (6.9%) patients were vaccinated. The effectiveness of vaccination assessed by the case-control method was estimated as 11% in prevention of admission with LCI SARI cases and 58% in prevention of LCI ILI/ARI cases. The concomitant somatic pathology and pregnancy were identified in 57.5% of SARI patients with LCI. This indicator was significantly higher (by 23.1%) in LCI SARI than in SARI caused by other respiratory pathogens. The leading role of pregnancy as a risk factor for hospitalization with LCI SARI (27.3% of SARI patients with influenza against 5.7% of SARI patients with other etiology) was confirmed in this season. In addition, significant increase (p < 0.05) of percentage of LCI SARI with cardiovascular diseases (16.5%) and diabetes (5.5%) compared to patients with SARI of other etiology (11.7 and 2.8% respectively) was established, and these patients’ categories were assigned to the risk groups.

RISK FACTORS FOR SARI AND INFLUENZA VACCINE EFFECTIVENESS IN SENTINEL SURVEILLANCE SYSTEM IN RUSSIA, THE SEASON 2017–2018