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Spidroin is the natural material possessed unique properties such as biocompatibility, noninflammatory property, controllable biodegradation, hydrophobicity. It can be used as functional biomaterial after processing and post-processing. In recent years the functional hybrid materials based on spidroin have been developed for the various biomedical and nanotechnological applications including drug delivery, tissue engineering, nanostructured optics, nanoelectronics, sensors, filtration, surface modification. In this study a hybrid consisting of spider silk and metal oxides that can generate active molecular forms as a result of interaction with peptides was investigated. Their biological properties were studied. Hybrid materials were obtained by precipitation of nanoparticles of tungsten and molybdenum oxides from hydrosol. The natural silk was obtained in insectarium where the spiders Linothele fallax are grown. A preliminary study was conducted on the activation of the web hybrids in a contact with two types of the test-microorganisms: gram-positive Staphylococcus aureus 209 R and gram-negative Escherichia coli XL-1. The study of antibacterial properties of hybrid silk-based material was carried out by agar diffusion method. The spider silk and their composites had a greater impact on the gram-positive type of bacteria itself. The results obtained for the hybrid material are comparable to the concentration dependence of the effect of nanoparticle solutions on bacterial cells. Moreover, a tendency for the synergistic effect of spider silk with deposited composite metal oxides on it was observed. In addition, there was a color change zone the dense medium. The colored area is considered as the result of interaction of a silk-based composite with the peptides of the medium and the exogenous proteins secreted by bacteria. The results show a positive trend that requires further study to verify the possibility of creating a new biomaterial as effective antibacterial complex.

A STUDY OF THE POTENTIAL OF SPIDER SILK USE FOR THE DEVELOPMENT OF ANTIBACTERIAL DRUGS