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The medical device ColdZyme is a mouth spray that forms a barrier in the throat against common cold viruses. The barrier solution of the device is composed of glycerol and Atlantic cod trypsin. The aim of this study was to evaluate the virus deactivating ability of ColdZyme against four major common cold viruses. A virucidal efficacy suspension test was conducted using ColdZyme against each of the challenge viruses in suspension. ColdZyme deactivated rhinovirus type 1A by 91.7% (1.08 log10), rhinovirus type 42 by 92.8% (1.14 log10), human influenza A virus H3N2 by 96.9% (1.51 log10), respiratory syncytial virus (RSV) by 99.9% (2.94 log10) and adenovirus type 2 by 64.5% (0.45 log10). Based on the results, ColdZyme showed an effective broad-spectrum impact against common cold viruses. Thus, ColdZyme might represent a device with clinical benefits in prevention and treatment of respiratory viral infections by deactivating viruses within the respiratory tract. Correspondence to: Bjarki Stefansson, Zymetech, Fiskislod 39, 101 Reykjavik, Iceland, Tel. +354-551-5400; E-mail: bjarkis@zymetech.com

A medical device forming a protective barrier that deactivates four major common cold viruses