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Objective: The association between physical function and the health-related quality of life (HRQOL) remains unclear in survivors of hematological malignancies undergoing hematopoietic stem cell transplantation (HSCT). The purpose of this study is to clarify the association between physical function and HRQOL in survivors of hematological malignancies undergoing HSCT. Methods: The present cross-sectional multicenter study included 32 survivors of hematological malignancies who underwent HSCT. Patient characteristics, physical function (based on handgrip strength, isometric knee extension strength, 6-minute walk test [6MWT], and chair stand test), HRQOL (assessed with the 36-Item Short-Form Health Survey [SF-36] questionnaire), depression, fatigue, and physical activity level were assessed. Results: A significant association was observed between physical function (chair stand test and 6MWT) and the physical functioning (PF) subscales of the SF-36 questionnaire. The PF, mental health, and social functioning (SF) subscales of the SF-36 questionnaire were significantly associated with depression and fatigue. Multiple logistic regression analysis showed that the physical component summary was significantly associated with depression and affective fatigue, and the PF score was significantly associated with the chair stand test and depression. The mental component summary showed that the physical role functioning, vitality, and SF scores were also significantly associated with depression. Conclusion: Physical function, depression, and fatigue were significantly associated with the HRQOL in survivors of hematological malignancies undergoing HSCT. *Correspondence to: Junichiro Inoue, RPT, PhD, Division of Rehabilitation Medicine, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 651-0017, Japan, Tel: +81-78-382-6494; Fax: +81-78-382-6499; E-mail address: jinoue@panda.kobe-u.ac.jp

trends in transplantation

Association between Physical Function and Health-related Quality of Life in Survivors of Hematological Malignancies undergoing Hematopoietic Stem Cell Transplantation