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Modafinil is recommended as a possible treatment for ADHD, narcolepsy, obstructive sleep apnea, and shift work disorder in adults but is not recommended by the FDA or manufacturer for use on pediatric patients due to some of the observed side effects in clinical studies [6]. Some of the observed side effects in adults include, but are not limited to, serious rash, depression, hallucinations, mania, irregular heartbeat, and troubled breathing [1]. In children, side effects seen in clinical studies include but are not limited to hostile behavior, low white blood cell count, increase in sudden loss of muscle tone, Tourette’s syndrome, and increases in suicidal thoughts [1]. There have not been many clinical studies that test the efficacy and safety of prescribing modafinil to children, especially as a treatment for narcolepsy and ADHD. While not recommended by the FDA, modafinil has on occasion been used off-label after brain surgery to treat disorders of wakefulness.

Modafinil for treatment of coma and unresponsiveness associated with edema of the reticular activating system (RAS) in a pediatric patient