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Circular RNAs (circRNAs) are a class of non-coding RNAs which is being explored recently. CircRNAs are highly conserved across species and exhibit tissue/ developmental stage-specific expression. circRNAs are more stable than linear mRNAs and lack a 5′-terminal cap and 3′-terminal poly A tail. CircRNAs modulate gene expression at the transcriptional and post-transcriptional levels. circRNAs play different functional roles in hallmark cancer events both as oncogens and tumor supressors including regulation of angiogenesis, induction of metastasis and invasion, evading cell death. Here, we outlined the molecular mechanisms of circRNA function to regulate the molecular events in cancer. We also reviewed the current knowledge and recent finding regarding the association of circRNA with head and neck cancer. We briefly discussed the potential of circRNA as diagnostic biomarkers as well as the possibility for therapeutic targeting. *Correspondence to: Fatemeh Momen-Heravi, Section of Oral, Diagnostic, and Rehabilitation Sciences, Columbia University, College of Dental Medicine, 630 W. 168 St., New York, NY 10032, USA, Tel 00-1-508-856-6794, Fax: 00-1-508856-4770, E-mail: shashi.bala@umassmed.edu

Circular RNAs in head and neck cancer diagnosis and potential molecular targeting