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Neovascularization of the cornea is one of the most serious complications that can arise as a result of disease or damage to the eye. Aim: to study the reparative properties of peptide solutions on the cornea. Materials and methods: The experiment was carried out on 20 rabbits in two stages: First stage: treatment of central thermal burns of the cornea without injury to the limbal region Second stage: treatment of peripheral thermal burns of the cornea with injury to the limbal region. The experimental groups underwent instillations with the peptide solution in the conjunctival cavity. The control groups were treated for thermal corneal burns by standard methods. The condition of all four groups of animals was monitored daily over a period of 14 days. After which, the follow up was carried out 3 times a week. On day 1, 3, 7, 14, and 30, the animals were removed from experimental conditions and the morphology of their respective corneas was evaluated. Results: By the 30th day, the corneal transparency in the experimental group was approaching the initial state and the corneal thickness had been restored. In the control group, the corneal transparency and thickness were lesser than the analogous results in the experimental group. In the experimental group, the structural integrity of the cornea was preserved while the endothelium showed a loss in cell density. In the control group there was formation of vascular cataracts and edema of the corneal stroma. Conclusions: After evaluating the results statistically, it can be concluded that tissue restoration is a lot faster with the use of peptide solutions.

Methods of treating keratitis and thermal burns in the cornea at various locations and areas with ligand-based peptides