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Right ventricle failure (RVF) contributes significantly to the morbidity and mortality in pulmonary hypertension (PH). The mechanical behavior of the RV is considered fundamental to its physiological function; however, the link between RV tissue biomechanics and organ function remains a key knowledge gap. We hypothesize that the RV passive elasticity is correlated with its in vivo function. In this study, we examined the relationships between the tissue mechanics and physiological function of the RV in healthy and PH sheep using a revised ovine model of pulmonary artery constriction. In vivo RV function was examined by echocardiography and hemodynamic measurement, and the RV passive elasticity was measured by ex vivo equibiaxial mechanical tests. We observed that the RV longitudinal stiffness was significantly increased and thus the anisotropic property was altered in PH sheep. This elasticity was significantly correlated with the long axis end-diastolic or end-systolic diameter/area. We further observed that in the outflow tract (longitudinal) direction, there were trends of correlations between the low-strain elastic modulus (EM) and the acceleration time, as well as between the high-strain EM and the deceleration time. These findings strongly indicate the critical role of RV passive mechanical properties in the organ function. *Correspondence to: Zhijie Wang, School of Biomedical Engineering, Colorado State University, Fort Collins, Colorado, USA, E-mail: zhijie.wang@colostate.edu

Correlations between the right ventricular passive elasticity and organ function in adult ovine