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Young male Zucker rats with a leptin receptor mutation are obese, have a non-insulin-dependent diabetes mellitus (NIDDM), and other endocrinopathies. Fine structure aspects of the tibial branches of the sciatic nerve of lean (Fa/?) and obese (fa/fa) perfused rats were compared and revealed a progressive demyelination caused by Schwann cells (SCs). There, stacked myelin layers membranes and other adhering junctions were defective in many nerve fibers of the obese rats, including of the mesaxons of the smallest fibers. Additionally, the progressive myelin alterations caused by metabolomic alterations in membrane components sorted by the SCs may also have revealed a peculiar, centripetal mode of sorting and trafficking maintenance of the peripheral nerve myelin. *Correspondence to: Jacques Gilloteaux, Department of Anatomical Sciences, St George’s University School of Medicine, UNN School of Health and Life Sciences, Drill Hall 013, Newcastle upon Tyne NE1 8ST, UK; and URPHyMNarilis, Départment de Médecine, Université de Namur, Rue de Bruxelles 61, Namur 5000, Belgium, E-mail: jgilloteaux@sgu.edu; jacques.gilloteaux@ unamur.be

brain and nerves

Peripheral nerve demyelination and a leptin receptor mutation: The obese Zucker rat sciatic nerve demyelination occurs with a centripetal pattern defect