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The mini-review is presented about the evolution of stress hormones (the components of hypothalamo-pituitary-adrenal axis) and stress proteins (heat shock proteins and others), as related to the concept of developmental origins of health and disease. The data on somatic growth retardation by glucocorticoids as mediators and targets of programming / imprinting phenomena are discussed in evolutionary aspect. Finally, two theoretical constructs are briefly introduced, the ontoand phylopatogenic model, with the last one having some perspectives of elaboration, as referred to biological evolution.

Evolution of stress hormones and proteins in relation to developmental origins of health and disease