English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Erectile Dysfunction (ED) affects 10 percent of the population worldwide. In 1995 it was estimated that 152 million men were affected by ED. It is estimated that by 2025 352 million of population worldwide will be affected. Currently there is not available treatment that can restore or regenerate the tissues in the corpus cavernosum or arterial system tthat will cure ED a 20 percent failure rate with present therapies and high rate of drop out in patients with ED due to radical prostatectomy and post radiation. Testosterone eplacement is the only independent risk factor that might help endothelial dysfunction and consequently ED. Adipose tissue is abundant and easy to collect from a miniliposuction. The procedure consists in collecting a lipoaspirate of 60 ml. No general Anesthesia is required. It is an outpatient procedure. Adipose tissue is processed using a non animal collagenase enzyme. Stromal vascular fraction (SVF) is isolated. Blood is obtained through a venipuncture. Platelet rich-plasma (PRP) is obtained. The SVF is suspended in PRP. The mixture is injected into the corpus cavernosum using our designed protocol for injection. Four types of patients: DM, ED due to prostatectomy and radiation, Peyronie’s disease, and ED organic cause/aging/vascular. Patients filled out the intensity score questionnaire before and after procedure. Both reported better erections in the morning, firmer, and better response to PDI5 inhibitors for which they were not responders prior to the treatment. This might be due to stem cells induced regeneration of the cavernous nerve and endothelial cells enhancing the nitric oxide production hence improved response to PDI-5 inhibitors. Abbreviations: ED: erectile dysfunction; SC: stem cells; ADSC: adipose-derived stem cell; BMSC: bone marrow stem Cell; SVF: stromal vascular fraction; CC: corpus cavernosum; IC: intracavernous: refers IC injections; SMCs: smooth muscle cells; CSMCs: corpus smooth muscle cells; CN: cavernous nerve; NO: nitric oxide; NOS: nitric oxide synthase; eNOS: endothelial nitric oxide: refers to NO coming from endothelial cells; nNOS: neuronal nitric oxide: refers to NO coming from nerve endings like CN; TA: tunica albuginea; DM: diabetes mellitus; PD: peyronie’s disease; CNI: cavernous nerve injury; MPG: major pelvic ganglion; RP: radical prostatectomy; PDE5 (I): phosphodiesterase type 5 (inhibitors); PVN: paraventricular nucleus; GTP: guanosine 5’-triphosphate.; cGMP: cyclic guanosine monophosphate; ATP: adenosine triphosphate; C AMP: adenosine monophosphate

integrative molecular medicine

Adipose-derived adult stem cells and new technique for intracavernosal injection for erectile dysfunction: novel approach to treat diabetes mellitus. Erectus Shot Technique