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Background: GI (glycemic index) is used to show the potency of foods to increase blood glucose. No research has been carried out about gender and age differences of GI of foods of distinct structures such as glucose and sucrose. We wanted to know if there is a big difference in GI depending upon sex and age to take foods. Methods: We gave 50 gm of either glucose or sucrose in a cross over study to three groups of healthy old (n=44, mean age: 62.4 ± 9.6), young men (n=36, mean age: 20.6 ± 1.6) and women (n= 35, mean age: 21.2 ± 0.7). Results: when GI of young men who took, glucose was set 100, GI of old men was 156. GI of young females who took sucrose was 55 When blood insulin levels of young men were set 100, insulin levels of old men who took sucrose were 30. Conclusion: GI of glucose of old men were 156% compared to GI of young men. GI of young females who took sucrose was 55% of GI of young men who took glucose. These results indicate that GIs were different between old and young men and young females even if they took the same foods with distinct structure such as glucose and sucrose. Introduction Term of glycemic index (GI) has been introduced by Jenkins and coworkers in 1981 [1] and is defined as the area under the blood glucose curve measured two hours after consuming 50 g of test carbohydrates in relation to 50 g of glucose. The use of GI has been controversial [2-5]. So far influences of gender or age on GI have not been studied. We showed that that GI is very much different between old and young men even if the same foods with distinct structures are given, and insulin release to increase in glucose in young men is more sensitive than old men even if the same foods with distinct structures are given [6]. We also showed that GI was influenced by gender [7]. We now summarized these results in this article. Methods Male and female college students or men older than 50 were requested to participate in the experiments. We carefully assessed their health and allowed those who do not smoke, with no sign of health problems such as diabetes and hypertension, as well as no history of serious disease, to participate. Participants were provided with a questionnaire relating to self-administered diets they may have followed in the past. From these completed questionnaires, we calculated their past intakes of energy, carbohydrate, fat, and protein. We did not calculate energy uptake related to alcohol drinks, but young men drink alcohol more than young women. Measurements of blood variables: After fasting overnight, participants were randomly assigned to groups. Depending on their group, each participant received a 550-mL solution containing 50 g of glucose or sucrose (or 500 mL water as a control). Either 50 g of glucose or sucrose was added and dissolved in each bottle containing 500 mL of water. Correspondence to: Takada A, International Projects on Food and Health (NPO), Sumida-ku Ishiwara 1-30-6-802, Tokyo 130-0011, Japan, Tel: 81338291849; Fax: 81338291847; E-mail: takadaa@mwd.biglobe.ne.jp

Gender and age differences of glycemic index in Japanese old men, young men and women