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Prostate cancer is a complex, heterogeneous and multifactorial disease. The high prevalence of prostatitis could contribute to prostate carcinogenesis, which is the second most common cause of cancer-related death in males. Unfavorable metabolic profiles such as hormonal imbalances, oxidative stress and inflammation in prostate disorders are associated with several complications. Different strategies of androgen deprivation for advanced prostate cancer are only palliative and rarely cure patients. Following the observed anti-hormonal property, anti-oxidative stress, and anti-inflammatory effects after a combination of dietary antioxidants supplementation in treatment of kidney stone in our original study, we have decided to determine the protective effect of this combination on prostate-specific antigen level. The data obtained from three groups out of eight groups of male Wistar rat (known as: Control, 4 and 8 week antioxidant group) to compare the PSA levels after antioxidants supplementation including, vitamins A, C, E and B6; zinc, selenium and boron. Group 1 (control) was fed a standard commercial diet. Group 2 and 3 received the same diet added with antioxidant nutrients for 4 and 8 week, respectively. Plasma samples collected for analysis. A significant decrease in the plasma concentration of malondialdehyde was noted in the treatment groups (G2 and G3). A marked decrease in the plasma concentration of active androgens (Testosterone, Free Testosterone, and Dihydrotestosterone) was noted in G2 after 4 week treatment. Estradiol concentration significantly increased in G2 and significantly decreased in G3 after 8 week treatment compared with G2. A significant reduction in concentration of CRP in G2 was noted. More specifically, a significant two and four fold lower plasma concentration of PSA was noted in the treatment groups. Data indicated the potential role of the antioxidants combination in decreasing the proposed risk factors of prostate, specifically the PSA level.

Antioxidants therapy: An alternative for androgen deprivation therapy (ADT) to decrease prostate-specific antigen (PSA) level