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CD73, also designated ecto-5′-nucleotidase is one kind of ecto-nucleotidase that plays a critical role in tumor development. CD73 overexpression is well established in the literature for various cancers. However, increasing studies have shown a strong relationship between CD73 for metastatic processes. In this review, we summarize major roles of CD73 expression for the development of metastases in different tumor tissues and possible therapeutic target for metastasis. In addition, we list possible CD73 functions, either by adenosine generation as adenosine receptor agonist (metastatic signaling modulator) or inorganic phosphate (Pi) generation as a substrate for the high bioenergetic metastatic processes demand. *Correspondence to: Marco Antonio Lacerda-Abreu and José Roberto MeyerFernandes, Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, CCS, Cidade Universitária, Rio de Janeiro, RJ 21941-590, Brazil, Tel: +55-21-3938-6781; Fax: +55-21-2270-8647; E-mail: meyer@bioqmed.ufrj.br

Possible roles of CD73 (ecto-5′-nucleotidase) and clinical significance in metastasis human cancer