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Background: A prospective, controlled study was carried out to determine the transepidermal penetration of a cosmeceutical after permeabilizing the skin using a device which combines radiofrequency and ultrasound. Material and methods: The Legato device (Alma Lasers) was used to introduce the fluorescein-stained PixelTreatSRTM cosmeceutical gel into the dermis. The treatments were performed in the retroauricular area in 16 patients, and biopsies were taken at 10 minutes and at 15 hours after the procedure. The intensity of dermal fluorescence in the treated samples was compared to that of Autofluorescence Controls (AC) and Technical Controls (TC). Results: The samples treated with the Legato device displayed a greater intensity of fluorescence than the AC and TC, both at 10 minutes and 15 hours. The increases in fluorescence were graded as moderate or intense, but in no case as nil or slight. The results at 10 minutes were: Legato (55.4 ± 10.1), AC (8.6 ± 2.8), TC (8.2 ± 3.6). At 15 hours, the results were: Legato (54.2 ± 7.2), AC (8.9 ± 1.7), TC (8.3 ± 2.4). The differences between the samples and the controls were significant, both at 10 minutes and at 15 hours (p<0.0008). Conclusion: The transepidermal delivery procedure carried out facilitated a prolonged and effective dermal penetration of the topically applied products.

global dermatology

Transepidermal delivery of cosmeceuticals using radiofrequency and ultrasound: Study of the penetration of a cosmetic gel in vivo by fluorescence microscopy