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The PNEI vision is centered on the role of the bi-directional crosstalk between the psychoneuroendocrine systems and the immune system managed by a complex network of signaling molecules which are the carriers of the biological information necessary for the homeostatic regulation of all cellular responses. An altered cross-talk due to an imbalance between specific signal molecules is proved to be fundamental for the onset of inflammatory, allergic and autoimmune diseases [7-9].

Low dose cytokine and the psycho-neuro-endocrine-immune approach in dermatology: Here is the future