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Saponins extracted from Polemonium caeruleum were studied as intranasal adjuvant by guinea pig intranasal immunization with trivalent influenza antigens. Sera titers of the animals immunized intranasally and control animals immunized intramuscularly were measured in HI and ELISA. On day 21 reciprocal GMT HI titers in group dually immunized intranasally were 201/64/31 against H1N1pdm09/H3N2/B components accordingly. Data obtained in ELISA shows that there was no statistically significant (P=0.95) differences in sera titers with control group of single intramuscularly immunized animals. Presented research shows that Polemonium caeruleum saponins can be studied as a candidate mucosal adjuvant for intranasal or oral viral or bacterial inactivated vaccines. *Correspondence to: Vasily Aleksandrovich Evseenko, State Research Centre of Virology and Biotechnology Vector (SRC VB “Vector”) Rospotrebnadzor, Koltsovo, Novosibirsk Region, 630559, Russian Federation, E-mail: evseenko_va@vector.nsc.ru; vasily.evseenko@gmail.com

Saponins extracted from Polemonium caeruleum have adjuvant activity in guinea pig intranasal immunization with trivalent influenza antigens